Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

Intramuscular vaccination with ChAdOx1 nCoV-19/AZD1222 protected rhesus macaques against pneumonia but did not reduce shedding of SARS-CoV-2. Here we investigate whether intranasally administered ChAdOx1 nCoV-19 reduces shedding, using a SARS-CoV-2 virus with the D614G mutation in the spike protein....

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: van Doremalen, Neeltje, Purushotham, Jyothi N., Schulz, Jonathan E., Holbrook, Myndi G., Bushmaker, Trenton, Carmody, Aaron, Port, Julia R., Yinda, Claude K., Okumura, Atsushi, Saturday, Greg, Amanat, Fatima, Krammer, Florian, Hanley, Patrick W., Smith, Brian J., Lovaglio, Jamie, Anzick, Sarah L., Barbian, Kent, Martens, Craig, Gilbert, Sarah, Lambe, Teresa, Munster, Vincent J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808328/
https://ncbi.nlm.nih.gov/pubmed/33447831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.09.426058
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