Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

ADAMTS-5 is a major protease involved in the turnover of proteoglycans such as aggrecan and versican. Dysregulated aggrecanase activity of ADAMTS-5 has been directly linked to the etiology of osteoarthritis (OA). For this reason, ADAMTS-5 is a pharmaceutical target for the treatment of OA. ADAMTS-5...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Santamaria, Salvatore, Cuffaro, Doretta, Nuti, Elisa, Ciccone, Lidia, Tuccinardi, Tiziano, Liva, Francesca, D’Andrea, Felicia, de Groot, Rens, Rossello, Armando, Ahnström, Josefin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806935/
https://ncbi.nlm.nih.gov/pubmed/33441904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80294-1
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