Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine

Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). The present work reports the design and synthesis of a hybrid of the precursors of rifampicin and clofazimine, which led to the discovery of a novel Rifaphenazine (RPZ) molecule with potent anti-TB ac...

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Udgivet i:Sci Rep
Main Authors: Saravanan, Pasupathy, Dusthackeer, V. N. Azger, Rajmani, R. S., Mahizhaveni, B., Nirmal, Christy R., Rajadas, Sam Ebenezer, Bhardwaj, Neerupma, Ponnuraja, C., Bhaskar, Adhin, Hemanthkumar, A. K., Ramachandran, Geetha, Tripathy, Srikanth P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806721/
https://ncbi.nlm.nih.gov/pubmed/33441878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80439-2
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