Discovery of a highly potent novel rifampicin analog by preparing a hybrid of the precursors of the antibiotic drugs rifampicin and clofazimine

Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). The present work reports the design and synthesis of a hybrid of the precursors of rifampicin and clofazimine, which led to the discovery of a novel Rifaphenazine (RPZ) molecule with potent anti-TB ac...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Saravanan, Pasupathy, Dusthackeer, V. N. Azger, Rajmani, R. S., Mahizhaveni, B., Nirmal, Christy R., Rajadas, Sam Ebenezer, Bhardwaj, Neerupma, Ponnuraja, C., Bhaskar, Adhin, Hemanthkumar, A. K., Ramachandran, Geetha, Tripathy, Srikanth P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806721/
https://ncbi.nlm.nih.gov/pubmed/33441878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80439-2
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