Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation

Introduction: Serine hydroxymethyltransferase 2 (SHMT2) plays a critical role in serine-glycine metabolism to drive cancer cell proliferation. However, the nonmetabolic function of SHMT2 in tumorigenesis, especially in human colorectal cancer (CRC) progression, remains largely unclear. Methods: SHMT...

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Dettagli Bibliografici
Pubblicato in:Theranostics
Autori principali: Liu, Chunqi, Wang, Liang, Liu, Xiaocong, Tan, Yuping, Tao, Lei, Xiao, Yuzhou, Deng, Pengchi, Wang, Huijuan, Deng, Qianyi, Lin, Yiyun, Jie, Hui, Zhang, Huaqin, Zhang, Jing, Peng, Yong, Zhang, Hu, Zhou, Zongguang, Sun, Qingxiang, Cen, Xiaobo, Zhao, Yinglan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2021
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806468/
https://ncbi.nlm.nih.gov/pubmed/33456583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.48699
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