O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is notably decreased in Alzheimer’s disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with neuroinflammation and tau pathology. However, the links among altered O-GlcNAcylation, β-amyloid (Aβ) accumulation, an...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Park, Jinsu, Ha, Hee-Jin, Chung, Eun Seon, Baek, Seung Hyun, Cho, Yoonsuk, Kim, Hark Kyun, Han, Jihoon, Sul, Jae Hoon, Lee, Jeongmi, Kim, Eunae, Kim, Junsik, Yang, Yong Ryoul, Park, Mikyoung, Kim, Sung Hyun, Arumugam, Thiruma V., Jang, Hyemin, Seo, Sang Won, Suh, Pann-Ghill, Jo, Dong-Gyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806231/
https://ncbi.nlm.nih.gov/pubmed/33523877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd3207
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