O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is notably decreased in Alzheimer’s disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with neuroinflammation and tau pathology. However, the links among altered O-GlcNAcylation, β-amyloid (Aβ) accumulation, an...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Park, Jinsu, Ha, Hee-Jin, Chung, Eun Seon, Baek, Seung Hyun, Cho, Yoonsuk, Kim, Hark Kyun, Han, Jihoon, Sul, Jae Hoon, Lee, Jeongmi, Kim, Eunae, Kim, Junsik, Yang, Yong Ryoul, Park, Mikyoung, Kim, Sung Hyun, Arumugam, Thiruma V., Jang, Hyemin, Seo, Sang Won, Suh, Pann-Ghill, Jo, Dong-Gyu
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806231/
https://ncbi.nlm.nih.gov/pubmed/33523877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd3207
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki