O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is notably decreased in Alzheimer’s disease (AD) brain. Necroptosis is activated in AD brain and is positively correlated with neuroinflammation and tau pathology. However, the links among altered O-GlcNAcylation, β-amyloid (Aβ) accumulation, an...

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Udgivet i:Sci Adv
Main Authors: Park, Jinsu, Ha, Hee-Jin, Chung, Eun Seon, Baek, Seung Hyun, Cho, Yoonsuk, Kim, Hark Kyun, Han, Jihoon, Sul, Jae Hoon, Lee, Jeongmi, Kim, Eunae, Kim, Junsik, Yang, Yong Ryoul, Park, Mikyoung, Kim, Sung Hyun, Arumugam, Thiruma V., Jang, Hyemin, Seo, Sang Won, Suh, Pann-Ghill, Jo, Dong-Gyu
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2021
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806231/
https://ncbi.nlm.nih.gov/pubmed/33523877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd3207
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