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8-cyanobenzothiazinone analogs with potent antitubercular activity
8-Nitrobenzothiazinones (BTZs) exemplified by macozinone are a new class of antitubercular agents with exceptionally potent activity. The aryl nitro group has been considered indispensable for activity since this is bioactivated within mycobacteria by the flavoenzyme DprE1 to a reactive nitroso meta...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Med Chem Res |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Springer US
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7805566/ https://ncbi.nlm.nih.gov/pubmed/33462533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-020-02676-4 |
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