Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1)

Hematopoietic progenitor kinase 1 (HPK1) is an intracellular kinase that plays an important role in modulating tumor immune response and thus is an attractive target for drug discovery. Crystallization of the wild-type HPK1 kinase domain has been hampered by poor expression in recombinant systems an...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Lau, Wai L., Pearce, Bradley, Malakian, Heather, Rodrigo, Iyoncy, Xie, Dianlin, Gao, Mian, Marsilio, Frank, Chang, Chiehying, Ruzanov, Max, Muckelbauer, Jodi K., Newitt, John A., Lipovšek, Daša, Sheriff, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2020
Assuntos:
Method Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7805552/
https://ncbi.nlm.nih.gov/pubmed/33439152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X20016015
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