Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, pot...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kim, Jung-Hwan, Matsubara, Tsutomu, Lee, Jaekwon, Fenollar-Ferrer, Cristina, Han, Kyungreem, Kim, Donghwan, Jia, Shang, Chang, Christopher J., Yang, Heejung, Nagano, Tomokazu, Krausz, Kristopher W., Yim, Sun-Hee, Gonzalez, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804329/
https://ncbi.nlm.nih.gov/pubmed/33436590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20461-0
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