Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells

BACKGROUND: There is a great need to discover factors that could protect pancreatic β-cells from apoptosis and thus prevent diabetes mellitus. Clusterin (CLU), a chaperone protein, plays an important role in cell protection in numerous cells and is involved in various cellular mechanisms, including...

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Vydáno v:Endocrinol Metab (Seoul)
Hlavní autoři: Hong, Seok-Woo, Lee, Jinmi, Kim, Min Jeong, Moon, Sun Joon, Kwon, Hyemi, Park, Se Eun, Rhee, Eun-Jung, Lee, Won-Young
Médium: Artigo
Jazyk:Inglês
Vydáno: Korean Endocrine Society 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803614/
https://ncbi.nlm.nih.gov/pubmed/33261311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3803/EnM.2020.768
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