δ-opioid receptor activation protects against Parkinson’s disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy

Our previous studies have shown that the δ-opioid receptor (DOR) is an important neuroprotector via the regulation of PTEN-induced kinase 1 (PINK1), a mitochondria-related molecule, under hypoxic and MPP(+) insults. Since mitochondrial dysfunctions are observed in both hypoxia and MPP(+) insults, th...

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Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Xu, Yuan, Zhi, Feng, Mao, Jiahao, Peng, Ya, Shao, Naiyuan, Balboni, Gianfranco, Yang, Yilin, Xia, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803568/
https://ncbi.nlm.nih.gov/pubmed/33197884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103970
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