PAX3-FOXO1 establishes myogenic super enhancers and confers BET bromodomain vulnerability

Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and adolescent young adults, driven primarily by the chimeric transcription factor PAX3-FOXO1 (P3F). The mechanisms by which P3F dysregulates chromatin are unknown. We find P3F reprograms the cis-regulatory landscape by indu...

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Publicado no:Cancer Discov
Main Authors: Gryder, Berkley E., Yohe, Marielle E., Chou, Hsien-Chao, Zhang, Xiaohu, Marques, Joana, Wachtel, Marco, Schaefer, Beat, Sen, Nirmalya, Song, Young, Gualtieri, Alberto, Pomella, Silvia, Rota, Rossella, Cleveland, Abigail, Wen, Xinyu, Sindiri, Sivasish, Wei, Jun S., Barr, Frederic G., Das, Sudipto, Andresson, Thorkell, Guha, Rajarshi, Lal-Nag, Madhu, Ferrer, Marc, Shern, Jack F., Zhao, Keji, Thomas, Craig J., Khan, Javed
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802885/
https://ncbi.nlm.nih.gov/pubmed/28446439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-1297
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