The SIRPα–CD47 immune checkpoint in NK cells

Here we report on the existence and functionality of the immune checkpoint signal regulatory protein α (SIRPα) in NK cells and describe how it can be modulated for cell therapy. NK cell SIRPα is up-regulated upon IL-2 stimulation, interacts with target cell CD47 in a threshold-dependent manner, and...

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Pubblicato in:J Exp Med
Autori principali: Deuse, Tobias, Hu, Xiaomeng, Agbor-Enoh, Sean, Jang, Moon K., Alawi, Malik, Saygi, Ceren, Gravina, Alessia, Tediashvili, Grigol, Nguyen, Vinh Q., Liu, Yuan, Valantine, Hannah, Lanier, Lewis L., Schrepfer, Sonja
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802363/
https://ncbi.nlm.nih.gov/pubmed/33416832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200839
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