Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity

[Image: see text] Azapeptide nitriles are postulated to reversibly covalently react with the active-site cysteine residue of cysteine proteases and form isothiosemicarbazide adducts. We investigated the interaction of azadipeptide nitriles with the cathepsin B1 drug target (SmCB1) from Schistosoma m...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Principais autores: Jílková, Adéla, Horn, Martin, Fanfrlík, Jindřich, Küppers, Jim, Pachl, Petr, Řezáčová, Pavlína, Lepšík, Martin, Fajtová, Pavla, Rubešová, Petra, Chanová, Marta, Caffrey, Conor R., Gütschow, Michael, Mareš, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802074/
https://ncbi.nlm.nih.gov/pubmed/33301315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00644
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