NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease

Intestinal microfold cells are the primary pathway for translocation of secretory IgA (SIgA)-pathogen complexes to gut-associated lymphoid tissue. Uptake of SIgA/commensals complexes is important for priming adaptive immunity in the mucosa. This study aims to explore the effect of SIgA retrograde tr...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Rochereau, Nicolas, Roblin, Xavier, Michaud, Eva, Gayet, Rémi, Chanut, Blandine, Jospin, Fabienne, Corthésy, Blaise, Paul, Stéphane
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801705/
https://ncbi.nlm.nih.gov/pubmed/33431850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20348-0
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