The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

The pool of β-Amyloid (Aβ) length variants detected in preclinical and clinical Alzheimer disease (AD) samples suggests a diversity of roles for Aβ peptides. We examined how a naturally occurring variant, e.g. Aβ(1–38), interacts with the AD-related variant, Aβ(1–42), and the predominant physiologic...

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Udgivet i:Sci Rep
Main Authors: Quartey, Maa O., Nyarko, Jennifer N. K., Maley, Jason M., Barnes, Jocelyn R., Bolanos, Maria A. C., Heistad, Ryan M., Knudsen, Kaeli J., Pennington, Paul R., Buttigieg, Josef, De Carvalho, Carlos E., Leary, Scot C., Parsons, Matthew P., Mousseau, Darrell D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801637/
https://ncbi.nlm.nih.gov/pubmed/33432101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80164-w
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