Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin

PURPOSE: The aim was to explore the correlation between increasing doses of [6R]-5,10-methylenetetrahydrofolate (arfolitixorin) and plasma concentrations of deoxyuridine (dUr) in patients with metastatic colorectal cancer (mCRC), subjected to 5-fluorouracil (5-FU)-based chemotherapy. The aim was fur...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Taflin, Helena, Odin, Elisabeth, Carlsson, Göran, Tell, Roger, Gustavsson, Bengt, Wettergren, Yvonne
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801297/
https://ncbi.nlm.nih.gov/pubmed/33099678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04173-2
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