Toxic Prediction of Pyrrolizidine Alkaloids and Structure-Dependent Induction of Apoptosis in HepaRG Cells

Pyrrolizidine alkaloids (PAs) are common phytotoxins and could cause liver genotoxicity/carcinogenicity following metabolic activation. However, the toxicity of different structures remains unclear due to the wide variety of PAs. In this study, the absorption, distribution, metabolism, excretion, an...

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Pubblicato in:Oxid Med Cell Longev
Autori principali: Zheng, Pimiao, Xu, Yuliang, Ren, Zhenhui, Wang, Zile, Wang, Sihan, Xiong, Jincheng, Zhang, Huixia, Jiang, Haiyang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7801077/
https://ncbi.nlm.nih.gov/pubmed/33488944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8822304
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