Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

Immune checkpoint blockade (ICB) has a limited effect on colorectal cancer, underlining the requirement of co‐targeting the complementary mechanisms. Here, we identified prostaglandin E2 (PGE(2)) receptor 4 (EP4) as the master regulator of immunosuppressive myeloid cells (IMCs), which are the major...

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Pubblicato in:EMBO Mol Med
Autori principali: Lu, Weiqiang, Yu, Weiwei, He, Jiacheng, Liu, Wenjuan, Yang, Junjie, Lin, Xianhua, Zhang, Yuanjin, Wang, Xin, Jiang, Wenhao, Luo, Jian, Zhang, Qiansen, Yang, Huaiyu, Peng, Shihong, Yi, Zhengfang, Ren, Shancheng, Chen, Jing, Siwko, Stefan, Nussinov, Ruth, Cheng, Feixiong, Zhang, Hankun, Liu, Mingyao
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799360/
https://ncbi.nlm.nih.gov/pubmed/33283987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012798
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