Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control

OBJECTIVES: To define key genetic elements, single or in clusters, underlying SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) evolutionary diversification across continents, and their impact on drug-binding affinity and viral antigenicity. METHODS: A total of 12 150 SARS-CoV-2 sequences...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Salpini, Romina, Alkhatib, Mohammad, Costa, Giosuè, Piermatteo, Lorenzo, Ambrosio, Francesca Alessandra, Di Maio, Velia Chiara, Scutari, Rossana, Duca, Leonardo, Berno, Giulia, Fabeni, Lavinia, Alcaro, Stefano, Ceccherini-Silberstein, Francesca, Artese, Anna, Svicher, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7799093/
https://ncbi.nlm.nih.gov/pubmed/33254234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa444
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