Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer

BACKGROUND: High levels of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) expression in tumour tissues are an indicator of ineffective responses to pemetrexed-based chemotherapy in various tumours, including non-small cell lung cancer (NSCLC). However, tumour tissues are highly heterog...

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Опубликовано в: :J Thorac Dis
Главные авторы: Li, Tao, Huang, Jin-Bo, Lu, Jun-Guo, Li, Rong, Wang, Yan, Shi, Xiang-Rong, Shi, Min-Xin, Zhang, Xiao-Dong
Формат: Artigo
Язык:Inglês
Опубликовано: AME Publishing Company 2020
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797849/
https://ncbi.nlm.nih.gov/pubmed/33447420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd-20-3185
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