Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes

AIM: In cardiomyocytes, transverse tubules (T-tubules) associate with the sarcoplasmic reticulum (SR), forming junctional membrane complexes (JMCs) where L-type calcium channels (LTCCs) are juxtaposed to Ryanodine receptors (RyR). Junctophilin-2 (JPH2) supports the assembly of JMCs by tethering T-tu...

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Bibliographic Details
Published in:Cardiovasc Res
Main Authors: Poulet, Claire, Sanchez-Alonso, Jose, Swiatlowska, Pamela, Mouy, Florence, Lucarelli, Carla, Alvarez-Laviada, Anita, Gross, Polina, Terracciano, Cesare, Houser, Steven, Gorelik, Julia
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797210/
https://ncbi.nlm.nih.gov/pubmed/32053184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvaa033
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