Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains

Introduction: We investigated the effect of partial mechanical unloading (PMU) of the heart on the physiology of calcium and beta-adrenoceptor-cAMP (βAR-cAMP) microdomains. Previous studies have investigated PMU using a model of heterotopic-heart and lung transplantation (HTHAL). These studies have...

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發表在:Front Physiol
Main Authors: Wright, Peter T., Sanchez-Alonso, Jose L., Lucarelli, Carla, Alvarez-Laviada, Anita, Poulet, Claire E., Bello, Sean O., Faggian, Giuseppe, Terracciano, Cesare M., Gorelik, Julia
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
Physiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157487/
https://ncbi.nlm.nih.gov/pubmed/30283354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01302
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