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Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism

The increasing availability of detailed structural information on many biological systems provides an avenue for manipulation of these structures, either for probing mechanism or for developing novel therapeutic agents for treating disease. This has been accompanied by the advent of several powerful...

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Publicado en:Bioorg Med Chem
Autor principal: Hinck, Andrew P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797196/
https://ncbi.nlm.nih.gov/pubmed/30026042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.07.008
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