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TGF-β antagonists: Same Knot, but Different Hold

In this issue of Structure, Nolan and colleagues present the structure of BMP antagonist, PRDC, which adopts a head-to-tail dimer with distinct structure and inhibitory mechanism compared to other dimeric antagonists of TGF-beta superfamily, such as noggin.

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Dettagli Bibliografici
Autori principali: Hinck, Andrew P., Huang, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809007/
https://ncbi.nlm.nih.gov/pubmed/23931139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.07.015
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