High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)

Nucleic acid therapeutics (NATs) have proven useful in promoting the degradation of specific transcripts, modifying gene expression, and regulating mRNA splicing. In each situation, efficient delivery of nucleic acids to cells, tissues and intracellular compartments is crucial—both for optimizing ef...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: He, Cuiwen, Migawa, Michael T, Chen, Kai, Weston, Thomas A, Tanowitz, Michael, Song, Wenxin, Guagliardo, Paul, Iyer, K Swaminathan, Bennett, C Frank, Fong, Loren G, Seth, Punit P, Young, Stephen G, Jiang, Haibo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
NAR Breakthrough Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797060/
https://ncbi.nlm.nih.gov/pubmed/33275144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1112
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