High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS

Cholesterol is a crucial lipid within the plasma membrane of mammalian cells. Recent biochemical studies showed that one pool of cholesterol in the plasma membrane is “accessible” to binding by a modified version of the cytolysin perfringolysin O (PFO*), whereas another pool is sequestered by sphing...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: He, Cuiwen, Hu, Xuchen, Jung, Rachel S., Weston, Thomas A., Sandoval, Norma P., Tontonoz, Peter, Kilburn, Matthew R., Fong, Loren G., Young, Stephen G., Jiang, Haibo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338444/
https://ncbi.nlm.nih.gov/pubmed/28167768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621432114
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