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Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene

The mammalian Ate1 gene encodes an arginyl transferase enzyme with tumor suppressor function that depends on the inclusion of one of the two mutually exclusive exons (MXE), exons 7a and 7b. We report that the molecular mechanism underlying MXE splicing in Ate1 involves five conserved regulatory intr...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kalinina, Marina, Skvortsov, Dmitry, Kalmykova, Svetlana, Ivanov, Timofei, Dontsova, Olga, Pervouchine, Dmitri D
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797038/
https://ncbi.nlm.nih.gov/pubmed/33330934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1208
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