Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene

The mammalian Ate1 gene encodes an arginyl transferase enzyme with tumor suppressor function that depends on the inclusion of one of the two mutually exclusive exons (MXE), exons 7a and 7b. We report that the molecular mechanism underlying MXE splicing in Ate1 involves five conserved regulatory intr...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Kalinina, Marina, Skvortsov, Dmitry, Kalmykova, Svetlana, Ivanov, Timofei, Dontsova, Olga, Pervouchine, Dmitri D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
RNA and RNA-protein complexes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797038/
https://ncbi.nlm.nih.gov/pubmed/33330934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1208
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