Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene

The mammalian Ate1 gene encodes an arginyl transferase enzyme with tumor suppressor function that depends on the inclusion of one of the two mutually exclusive exons (MXE), exons 7a and 7b. We report that the molecular mechanism underlying MXE splicing in Ate1 involves five conserved regulatory intr...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Kalinina, Marina, Skvortsov, Dmitry, Kalmykova, Svetlana, Ivanov, Timofei, Dontsova, Olga, Pervouchine, Dmitri D
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
RNA and RNA-protein complexes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797038/
https://ncbi.nlm.nih.gov/pubmed/33330934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1208
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