APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A

Many APOBEC cytidine deaminase members are known to induce ‘off-target’ cytidine deaminations in 5′TC motifs in genomic DNA that contribute to cancer evolution. In this report, we characterized APOBEC1, which is a possible cancer related APOBEC since APOBEC1 mRNA is highly expressed in certain types...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Wong, Lai, Vizeacoumar, Frederick S, Vizeacoumar, Franco J, Chelico, Linda
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797036/
https://ncbi.nlm.nih.gov/pubmed/33330905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1201
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