GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner

GNA13, encoding one of the G protein alpha subunits of heterotrimeric G proteins that transduce signals of G protein-coupled receptors (GPCR), is frequently mutated in germinal center B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) with poor prognostic outcomes. Due to the “undruggable” nature...

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Udgivet i:Cell Death Dis
Main Authors: Xia, Zhizhou, Zhang, Xiuli, Liu, Ping, Zhang, Ruihong, Huang, Zhangsen, Li, Donghe, Xiao, Xinhua, Wu, Min, Ning, Nannan, Zhang, Qianqian, Zhang, Jianmin, Liu, Mingzhu, Jiao, Bo, Ren, Ruibao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797003/
https://ncbi.nlm.nih.gov/pubmed/33423045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03311-1
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