Genetic screening for single-cell variability modulators driving therapy resistance

Cellular plasticity describes cells’ ability to transition from one set of phenotypes to another. In melanoma, transient fluctuations in the molecular state of tumor cells mark the formation of rare cells primed to survive BRAF inhibition and reprogram into a stably drug resistant fate. However, the...

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Publicado en:Nat Genet
Autores principales: Torre, Eduardo A., Arai, Eri, Bayatpour, Sareh, Jiang, Connie L., Beck, Lauren E., Emert, Benjamin L., Shaffer, Sydney M., Mellis, Ian A., Fane, Mitchell E., Alicea, Gretchen M., Budinich, Krista A., Weeraratna, Ashani T., Shi, Junwei, Raj, Arjun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796998/
https://ncbi.nlm.nih.gov/pubmed/33398196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00749-z
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