Genetic screening for single-cell variability modulators driving therapy resistance

Cellular plasticity describes cells’ ability to transition from one set of phenotypes to another. In melanoma, transient fluctuations in the molecular state of tumor cells mark the formation of rare cells primed to survive BRAF inhibition and reprogram into a stably drug resistant fate. However, the...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Torre, Eduardo A., Arai, Eri, Bayatpour, Sareh, Jiang, Connie L., Beck, Lauren E., Emert, Benjamin L., Shaffer, Sydney M., Mellis, Ian A., Fane, Mitchell E., Alicea, Gretchen M., Budinich, Krista A., Weeraratna, Ashani T., Shi, Junwei, Raj, Arjun
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796998/
https://ncbi.nlm.nih.gov/pubmed/33398196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00749-z
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