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The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels essential for glutamatergic transmission and plasticity. NMDARs are inhibited by acute ethanol and undergo brain region specific adaptations after chronic alcohol exposure. In previous studies, we reported that knock-in mice ex...

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發表在:Psychopharmacology (Berl)
Main Authors: Zamudio, Paula A., Gioia, Dominic A., Lopez, Marcelo, Homanics, Gregg E., Woodward, John J.
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796987/
https://ncbi.nlm.nih.gov/pubmed/33052417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-020-05680-z
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