Simultaneous activation of the small conductance calcium activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles

BACKGROUND: Concomitant apamin-sensitive small conductance, calcium activated potassium current (I(KAS)) activation and I(Na) inhibition induce J-wave syndrome (JWS) in rabbit hearts. Sudden death in JWS occurs predominantly in men at night, when parasympathetic tone is strong. OBJECTIVE: To test th...

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Publicado en:Heart Rhythm
Main Authors: Fei, Yu-Dong, Chen, Mu, Guo, Shuai, Ueoka, Akira, Chen, Zhenhui, Rubart-von der Lohe, Michael, Everett, Thomas H., Qu, Zhilin, Weiss, James N., Chen, Peng-Sheng
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796982/
https://ncbi.nlm.nih.gov/pubmed/32763429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2020.07.036
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