Sex‐specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles

KEY POINTS: It is unknown if a sex difference exists in cardiac apamin‐sensitive small conductance Ca(2+)‐activated K(+) (SK) current (I (KAS)). There is no sex difference in I (KAS) in the basal condition. However, there is larger I (KAS) in female rabbit ventricles than in male during isoprotereno...

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Udgivet i:J Physiol
Main Authors: Chen, Mu, Yin, Dechun, Guo, Shuai, Xu, Dong‐Zhu, Wang, Zhuo, Chen, Zhenhui, Rubart‐von der Lohe, Michael, Lin, Shien‐Fong, Everett, IV, Thomas H., Weiss, James N., Chen, Peng‐Sheng
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Cardiovascular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138290/
https://ncbi.nlm.nih.gov/pubmed/29917243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275681
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