Ondansetron effects on apamin-sensitive small conductance calcium-activated potassium currents in pacing induced failing rabbit hearts

BACKGROUND: Ondansetron, a widely prescribed antiemetic, has been implicated in drug-induced long QT syndrome. Recent patch clamp experiments have shown that ondansetron inhibits the apamin sensitive calcium activated potassium current (I(KAS)). OBJECTIVE: To determine if ondansetron causes action p...

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Detalhes bibliográficos
Publicado no:Heart Rhythm
Main Authors: Yin, Dechun, Yang, Na, Tian, Zhipeng, Wu, Adonis Z., Xu, Dongzhu, Chen, Mu, Kamp, Nicholas J, Wang, Zhuo, Shen, Changyu, Chen, Zhenhui, Lin, Shien-Fong, Rubart-von der Lohe, Michael, Chen, Peng-Sheng, Everett, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982558/
https://ncbi.nlm.nih.gov/pubmed/31513946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2019.09.008
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