Heme oxygenase-1 inhibition promotes IFNγ and NOS2 mediated control of Mycobacterium tuberculosis infection

Mycobacterium tuberculosis (Mtb) infection induces pulmonary expression of the heme-degrading enzyme heme oxygenase-1 (HO-1). We have previously shown that pharmacological inhibition of HO-1 activity in experimental tuberculosis results in decreased bacterial loads and unexpectedly that this outcome...

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Bibliografiske detaljer
Udgivet i:Mucosal Immunol
Main Authors: Costa, Diego L, Amaral, Eduardo P, Namasivayam, Sivaranjani, Mittereder, Lara R, Fisher, Logan, Bonfim, Caio C, Sardinha-Silva, Aline, Thompson, Robert W, Hieny, Sara E, Andrade, Bruno B, Sher, Alan
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796944/
https://ncbi.nlm.nih.gov/pubmed/32862202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-020-00342-x
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