Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes

Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the e...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Costa, Diego L., Namasivayam, Sivaranjani, Amaral, Eduardo P., Arora, Kriti, Chao, Alex, Mittereder, Lara R., Maiga, Mamoudou, Boshoff, Helena I., Barry, Clifton E., Goulding, Celia W., Andrade, Bruno B., Sher, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Observation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080384/
https://ncbi.nlm.nih.gov/pubmed/27795400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01675-16
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