Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes

Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the e...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Costa, Diego L., Namasivayam, Sivaranjani, Amaral, Eduardo P., Arora, Kriti, Chao, Alex, Mittereder, Lara R., Maiga, Mamoudou, Boshoff, Helena I., Barry, Clifton E., Goulding, Celia W., Andrade, Bruno B., Sher, Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Observation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080384/
https://ncbi.nlm.nih.gov/pubmed/27795400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01675-16
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