Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes

Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whether the e...

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Veröffentlicht in:mBio
Hauptverfasser: Costa, Diego L., Namasivayam, Sivaranjani, Amaral, Eduardo P., Arora, Kriti, Chao, Alex, Mittereder, Lara R., Maiga, Mamoudou, Boshoff, Helena I., Barry, Clifton E., Goulding, Celia W., Andrade, Bruno B., Sher, Alan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
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Observation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080384/
https://ncbi.nlm.nih.gov/pubmed/27795400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01675-16
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