First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease towards which pleiotropic approach using Multi-Target Directed Ligands is nowadays recognized as probably convenient. Among the numerous targets which are today validated against AD, acetylcholinesterase (ACh) and Monoamine Oxida...

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Publicado no:Molecules
Main Authors: Guieu, Benjamin, Lecoutey, Cedric, Legay, Rémi, Davis, Audrey, Sopkova de Oliveira Santos, Jana, Altomare, Cosimo Damiano, Catto, Marco, Rochais, Christophe, Dallemagne, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7795340/
https://ncbi.nlm.nih.gov/pubmed/33375412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26010080
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