Serotonin/5-HT1A Signaling in the Neurovascular Unit Regulates Endothelial CLDN5 Expression

We previously reported that site-selective claudin-5 (CLDN5) breakdown and protein kinase A (PKA) activation are observed in brain microvessels of schizophrenia, but the underlying molecular basis remains unknown. The 5-HT1 receptors decline the intracellular cAMP levels and inactivate the major dow...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Sugimoto, Kotaro, Ichikawa-Tomikawa, Naoki, Nishiura, Keisuke, Kunii, Yasuto, Sano, Yasuteru, Shimizu, Fumitaka, Kakita, Akiyoshi, Kanda, Takashi, Imura, Tetsuya, Chiba, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7795278/
https://ncbi.nlm.nih.gov/pubmed/33383868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010254
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