Multiple Recombination Events and Strong Purifying Selection at the Origin of SARS-CoV-2 Spike Glycoprotein Increased Correlated Dynamic Movements

Our evolutionary and structural analyses revealed that the severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) spike gene is a complex mosaic resulting from several recombination events. Additionally, the fixation of variants has mainly been driven by purifying selection, suggesting...

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Publicat a:Int J Mol Sci
Autors principals: Tagliamonte, Massimiliano S., Abid, Nabil, Borocci, Stefano, Sangiovanni, Elisa, Ostrov, David A., Kosakovsky Pond, Sergei L., Salemi, Marco, Chillemi, Giovanni, Mavian, Carla
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794730/
https://ncbi.nlm.nih.gov/pubmed/33374797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010080
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