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Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations

Many heritable genetic disorders arise from nonsense mutations, which generate premature termination codons (PTCs) in transcribed mRNA. PTCs ablate protein synthesis by prematurely terminating the translation of mutant mRNA, as well as reducing mutant mRNA quantity through targeted degradation by no...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: McHugh, Daniel R., Cotton, Calvin U., Hodges, Craig A.
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7794695/
https://ncbi.nlm.nih.gov/pubmed/33396210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010344
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