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A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies
Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and lead to lack of CFTR function. There are no currently available animal models which contain a nonsense mutation in the endogenous Cftr locus tha...
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| Izdano u: | PLoS One |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6010256/ https://ncbi.nlm.nih.gov/pubmed/29924856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199573 |
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