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Nonaminoglycoside compounds induce readthrough of nonsense mutations
Large numbers of genetic disorders are caused by nonsense mutations for which compound-induced readthrough of premature termination codons (PTCs) might be exploited as a potential treatment strategy. We have successfully developed a sensitive and quantitative high-throughput screening (HTS) assay, p...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757881/ https://ncbi.nlm.nih.gov/pubmed/19770270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081940 |
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