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Screening Readthrough Compounds to Suppress Nonsense Mutations: Possible Application to β-Thalassemia
Several types of thalassemia (including β(0)39-thalassemia) are caused by nonsense mutations in genes controlling globin production, leading to premature translation termination and mRNA destabilization mediated by the nonsense mediated mRNA decay. Drugs (for instance, aminoglycosides) can be design...
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| Publicado no: | J Clin Med |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7073686/ https://ncbi.nlm.nih.gov/pubmed/31972957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9020289 |
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