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Screening Readthrough Compounds to Suppress Nonsense Mutations: Possible Application to β-Thalassemia
Several types of thalassemia (including β(0)39-thalassemia) are caused by nonsense mutations in genes controlling globin production, leading to premature translation termination and mRNA destabilization mediated by the nonsense mediated mRNA decay. Drugs (for instance, aminoglycosides) can be design...
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| 出版年: | J Clin Med |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7073686/ https://ncbi.nlm.nih.gov/pubmed/31972957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9020289 |
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