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UPF1 silenced cellular model systems for screening of read-through agents active on β(0)39 thalassemia point mutation
BACKGROUND: Nonsense mutations promote premature translational termination, introducing stop codons within the coding region of mRNAs and causing inherited diseases, including thalassemia. For instance, in β(0)39 thalassemia the CAG (glutamine) codon is mutated to the UAG stop codon, leading to prem...
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| Publié dans: | BMC Biotechnol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5952824/ https://ncbi.nlm.nih.gov/pubmed/29764417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-018-0435-0 |
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